Neuropeptides originating in scorpion

Details Neuropeptides originating in scorpion Neuropeptides originating in scorpion

C - Chemistry, Metallurgy

07

K

C07K 14/435 (2006.01) A61K 38/17 (2006.01) A61P 37/06 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2247328

The invention provides a peptide capable of blocking voltage-gated K+ channels and inhibiting IL-2 production, which is represented by an amino acid sequence of: Ala-Ser-Cys-Arg-Thr-Pro-Lys-Asp-Cys-Ala-Asp-Pro-Cys-Arg-Lys- Glu-Thr-Gly-Cys-Pro-Tyr-Gly-Lys-Cys-Met-Asn-Arg-Lys-Cys-Lys-Cys-Asn-Arg-Cys; in which the C-terminal is amidated and four disulfide bridges are present in the molecule, and their related peptides isolated from the venom gland of a scorpion Heterometrus spinnifer. The peptides provided by the present invention are neuropeptides which can block voltage-gated K+ channels and inhibit IL-2 production at an extremely low concentration and, therefore, are expected to contribute to application of scorpion toxins to medicines and so on.

Cette invention concerne le peptide représenté par la séquence d'acides aminés suivante, qui a subi une transformation amide au niveau de son extrémité C-terminale et qui porte quatre liaisons bisulfure dans sa molécule: Ala-Ser-Cys-Arg-Thr-Pro-Lys-Asp-Cys-Ala-Asp-Pro-Cys-Arg-Lys-Glu-Thr-Gly-Cys-Pro-Tyr-Gly-Lys-Cys-Met-Asn-Arg-Lys-Cys-Lys-Cys-Asn-Arg-Cys, qui inhibe la production de Il-2 en bloquant le canal K<+> dépendant de la tension et est isolée à partir d'une glande à venin d'un scorpion Heterometrus spinnifer. L'invention se rapporte également à des peptides analogues du peptide décrit ci-dessus. Ces peptides sont des neuropeptides qui possèdent des activités, à une concentration extrêmement faible, de blocage du canal K<+> dépendant de la tension et qui, de ce fait, inhibent la production d'IL-2 et peuvent être utilisés dans des médicaments dirigés contre la toxine du scorpion, etc.

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