Neuropilin antisense oligonucleotide sequences and methods...

Details Neuropilin antisense oligonucleotide sequences and methods... Neuropilin antisense oligonucleotide sequences and methods...

C - Chemistry, Metallurgy

12

N

C12N 15/11 (2006.01) A61K 31/70 (2006.01) C07H 21/00 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2326824

This invention relates to oligonucleotides complementary to the neuropilin genes which modulate tumor cell growth and angiogenesis in mammals. This invention is also related to methods of using such compounds in inhibiting the growth of tumor cells and angiogenesis in mammals. This invention also relates to pharmaceutical compositions comprising a pharmaceutically acceptable excipient and an effective amount of a compound of this invention.

L'invention concerne des oligonucléotides complémentaires des gènes de neuropiline qui modulent la croissance des cellules tumorales et l'angiogenèse chez les mammifères. Elle se rapporte également à des procédés associés d'utilisation desdits composés dans l'inhibition de la croissance des cellules tumorales et de l'angiogenèse chez les mammifères. Elle porte encore sur des compositions pharmaceutiques comprenant un excipient acceptable au plan pharmaceutique et une dose efficace du composé de l'invention.

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