Neuroprotectant methods, compositions, and screening methods...

A - Human Necessities – 61 – K

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A61K 31/4172 (2006.01) A61K 31/355 (2006.01) A61K 31/375 (2006.01) A61P 39/06 (2006.01)

Patent

CA 2480227

The present invention relates in general to methods of protecting a mammalian central nervous system cell from damage, and to methods of treating or ameliorating neurodegenerative diseases. The invention further relates to screening for neuroprotective agents that may alone, or in combination with other neuroprotective agents, aid in protecting cells of the central nervous system from damage attributed to neurotoxic compounds, free radicals, or neurodegenerative diseases. The invention further relates to pharmaceutical compositions comprising L~-ergothioneine or other newly identified compounds and pharmaceutically acceptable carriers for administration to a mammal in need of neuroprotection.

L'invention concerne de manière générale des méthodes permettant de protéger une cellule du système nerveux central d'un mammifère contre des lésions, et des méthodes permettant de traiter ou de soulager des maladies neurodégénératives. L'invention concerne également le criblage d'agents neuroprotecteurs qui peuvent, seuls ou en combinaison avec d'autres agents neuroprotecteurs, contribuer à la protection de cellules du système nerveux central contre des lésions attribuées à des composés neurotoxiques, à des radicaux libres, ou à des maladies neurodégénératives. L'invention concerne en outre des compositions pharmaceutiques comprenant de la L-ergothionéine ou d'autres composés récemment identifiés et des vecteurs pharmaceutiquement acceptables, destinées à une administration à un mammifère nécessitant une neuroprotection.

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