Neuroprotective agents and methods of their use

Details Neuroprotective agents and methods of their use Neuroprotective agents and methods of their use

A - Human Necessities

61

P

A61P 25/16 (2006.01) A61K 38/02 (2006.01) A61K 38/16 (2006.01) A61K 48/00 (2006.01) A61P 25/28 (2006.01)

Patent

CA 2597335

This invention is related to a method of controlling neurodegeneration by increasing CD 147 receptor signalling. Neuroprotection can be achieved using cyclophilin A or a functional variant, analog or derivative as a ligand for the CD 147 receptor administered in various means including gene therapy. Conditions treatable with this method include cerebral ischemia, Alzheimer's Disease, Parkinson's Disease, Motor Neurone Disease and/or neuronal loss due to trauma and spinal cord damage.

La présente invention concerne une méthode de régulation de la neurodégénérescence par augmentation de la signalisation du récepteur CD 147. L'effet neuroprotecteur peut être obtenu par administration suivant diverses méthodes, incluant la thérapie génique, de la cyclophiline A ou d'une variante fonctionnelle, d~un analogue ou d'un dérivé de ladite molécule en tant que ligand du récepteur CD 147. Les états pathologiques pouvant être traités à l'aide de cette méthode incluent l'ischémie cérébrale, la maladie d'Alzheimer, la maladie de Parkinson, la maladie de Charcot et/ou la perte de neurones du fait de traumatismes ou de dégâts à la moelle épinière.

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