Neuroprotective agents and methods related thereto

Details Neuroprotective agents and methods related thereto Neuroprotective agents and methods related thereto

C - Chemistry, Metallurgy

07

D

C07D 213/55 (2006.01) A61K 31/44 (2006.01) A61P 25/00 (2006.01) C07C 323/59 (2006.01) C07D 213/50 (2006.01) C07D 213/56 (2006.01) C07D 213/81 (2006.01) C07D 239/26 (2006.01) C07D 277/24 (2006.01) C07D 277/64 (2006.01) C07D 401/12 (2006.01) C07D 401/14 (2006.01) C07D 405/12 (2006.01) C07D 407/12 (2006.01) C07D 409/12 (2006.01) C07D 413/12 (2006.01) C07D 417/12 (2006.01) C07D 495/04 (2006.01)

Patent

CA 2388239

Neuroprotective agents are disclosed having structure (I) wherein R1, R2, R3, R4 and R5 are as defined herein. Such compounds have utility in the treatment of conditions which benefit from administration of neuroprotective agents generally, including treatment of central and peripheral nervous condition as well as for promoting nerve cell differentiation. Methods of treating such conditions are also disclosed, as are pharmaceutical compositions containing one or more of the compounds of this invention.

L'invention se rapporte à des agents neuroprotecteurs représentés par la formule (I), dans laquelle R¿1?, R¿2?, R¿3?, R¿4? et R¿5? sont définis dans la description associée. Ces composés s'avèrent utiles pour le traitement des troubles qui bénéficient de l'administration d'agents neuroprotecteurs de manière générale, et notamment pour le traitement des troubles nerveux centraux et périphériques, ainsi que pour favoriser la différentiation des cellules nerveuses. L'invention se rapporte également à des méthodes de traitement des troubles ci-dessus ainsi qu'à des compositions pharmaceutiques contenant un ou plusieurs de ces agents neuroprotecteurs.

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