C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 403/14 (2006.01) A61K 31/40 (2006.01) A61K 31/415 (2006.01) A61K 31/435 (2006.01) A61K 31/47 (2006.01) A61K 45/06 (2006.01) A61P 25/28 (2006.01) A61P 29/00 (2006.01) A61P 35/00 (2006.01) C07D 403/04 (2006.01) C07D 487/04 (2006.01) C07D 487/22 (2006.01)
Patent
CA 2409355
This invention features ring-substituted pyrrolo-.beta.-carboline derivatives and ring-substitution and structural derivatives of 3-(1H-indol-3-yl)-1H- pyrrole-2,5-dione of formulas (I - III), which are useful as neuroprotective and anti-proliferative compounds. Also disclosed are methods for the preparation of these compounds, selected biological profiles and uses of these compounds in the treatment of various neurodegenerative and inflammatory diseases of the human nervous system and in the treatment of various other proliferative disorders characterized by loss of growth or cellular differentiation control including, but not limited to, cancer and inflammation.
L'invention concerne des dérivés pyrrolo-.szlig.-carboline de substitution, la substitution de cycles et des dérivés structuraux de 3-(1<i>H</i>-indol-3-yl)-1<i>H</i>-pyrrole-2,5-dione de formules (I-III), utiles comme composés neuroprotecteurs et anti-prolifératifs. L'invention concerne également des procédés de préparation de ces composés, des profils biologiques sélectionnés et des utilisations de ces composés dans le traitement de différentes maladies neurodégénératives et inflammatoires du système nerveux central et dans le traitement de différents troubles prolifératifs caractérisés par la perte de régulation de la croissance ou de la différenciation cellulaire, dont, entre autres, les cancers et les inflammations.
Fallis Alex
Gillard John
Jaquith James B.
Aegera Therapeutics Inc.
Borden Ladner Gervais Llp
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