Neuroprotective compositions and methods

Details Neuroprotective compositions and methods Neuroprotective compositions and methods

C - Chemistry, Metallurgy

07

C

C07C 69/757 (2006.01) A61K 31/191 (2006.01) A61K 31/215 (2006.01) A61P 25/00 (2006.01) C07C 39/17 (2006.01) C07C 62/32 (2006.01) C07C 62/38 (2006.01) C07C 69/21 (2006.01)

Patent

CA 2666461

Neurite outgrowth-promoting prostaglandins (NEPPs) and other electrophilic compounds bind to Keapl, a negative regulator of the transcription factor Nrf2, and prevent Keapl -mediated inactivation of Nrf2 and, thus, enhance Nrf2 translocation into the nucleus of neuronal cells. Therefore, neuroprotective compositions and related methods are provided that employ such neuroprotective compounds, and prodrugs of such compounds, to cause dissociation of Nrf2 from a Keapl /Nrf2 complex.

Des prostaglandines de croissance neuritique (NEPP) et d'autres composés électrophiles se lient à Keap1, régulateur négatif du facteur de transcription Nrf2, et empêchent l'activation de Nrf2 à médiation par Keap1; elles favorisent ainsi la translocation de Nrf2 dans le noyau de cellules neuronales. Cela permet d'obtenir des compositions neuroprotectrices et des procédés correspondants qui utilisent ces composants neuroprotecteurs ainsi que des promédicaments de ces composés, pour provoquer la dissociation de Nrf2 d'avec le complexe Keap1/Nrf2.

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