Neuroprotective compounds

Details Neuroprotective compounds Neuroprotective compounds

C - Chemistry, Metallurgy

07

D

C07D 471/22 (2006.01) A61K 31/4045 (2006.01) A61K 31/437 (2006.01) A61K 31/4375 (2006.01) A61K 31/7056 (2006.01) A61K 31/706 (2006.01) A61P 9/10 (2006.01) A61P 25/00 (2006.01) A61P 35/00 (2006.01) C07D 401/14 (2006.01) C07D 403/04 (2006.01) C07D 403/08 (2006.01) C07D 403/14 (2006.01) C07D 409/14 (2006.01) C07D 471/04 (2006.01) C07D 487/14 (2006.01) C07H 5/06 (2006.01)

Patent

CA 2308994

This invention features ring-substituted .beta.-carboline derivatives of the indolocarbazole K252a, and ring-substitution and structural derivatives of 3-(1H-indol-3-yl)- 1H-pyrroledione which are useful as neuroprotective compounds. Also disclosed are methods for the preparation of these compounds, selected biological profiles, and uses of these compounds in the treatment of various neurodegenerative and inflammatory diseases, and in the treatment of various other disorders characterized by loss of growth and cellular differentiation control; cancer, inflammation, and various human and viral signal transduction processes.

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