Neuroprotective compounds and uses thereof

Details Neuroprotective compounds and uses thereof Neuroprotective compounds and uses thereof

A - Human Necessities

61

K

A61K 31/16 (2006.01) C07C 233/18 (2006.01) C07C 235/02 (2006.01)

Patent

CA 2287162

The present invention relates to a compound having formula (I) where X = R1O, F, Br, I, C1, or a C1 to C5 alkyl group; R1 = a C1 to C10 alkyl group or a C1 to C10 aryl group, n = 1 or 2, R2 = aC1 to C6 alkyl group, an amino acid, a heterocycle, a secondary or tertiary C3 to C4 hydrocarbon, or (a) where R3 = H or CH3, or pharmaceutically acceptable salts thereof. The invention further relates to pharmaceutical compositions which include the compounds, as well as methods of making and using the compounds.

Cette invention porte sur un composé répondant à la formule: (I) dans laquelle X représente R¿1?O, F, Br, I, Cl ou un groupe alkyle comportant de 1 à 5 atomes de carbone, R¿1? représente un groupe alkyle comportant de 1 à 10 atomes de carbone ou un groupe aryle comportant de 1 à 10 atomes de carbone, n vaut 1 ou 2, R¿2? représente un groupe alkyle comportant de 1 à 6 atomes de carbone, un acide aminé, un hétérocycle, un hydrocarbure secondaire ou tertiaire comportant de 3 à 4 atomes de carbone ou représente la formule (a), formule dans laquelle R¿3? représente H ou CH¿3?. L'invention, qui concerne également les sels de ce composé, acceptables du point de vue pharmaceutique, porte, en outre, sur des compositions pharmaceutiques renfermant ces composés ainsi que sur leurs techniques de production et d'utilisation.

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