Neuroprotective effect of solubilized udca in focal ischemic...

A - Human Necessities – 61 – K

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A61K 31/575 (2006.01) A61K 9/00 (2006.01) A61K 47/36 (2006.01) A61P 25/00 (2006.01)

Patent

CA 2577268

The present disclosure provides compositions and methods for treating, ameliorating, or relieving at least one symptom associated with loss of blood flow to the brain including, without limitation, ischemic stroke. Compositions of the disclosure may comprise a bile acid compound and a carbohydrate, wherein both materials remain in solution for all pH values of the solution within a selected range of pH values. Symptoms may include infarct volume, functional recovery, apoptosis, and/or eNOS expression.

L'invention concerne des compositions et des méthodes pour traiter, améliorer, ou soulager au moins un symptôme associé à une perte d'écoulement sanguin au cerveau, comprenant, de manière non exhaustive, un accident ischémique cérébral. Les compositions de l'invention peuvent comprendre un composé acide de la bile et un glucide, ces deux matières restant dans la solution pour toutes les valeurs de pH de la solution comprises à l'intérieur d'une plage sélectionnée de valeurs de pH. Les symptômes peuvent comprendre un volume d'infarctus, une récupération fonctionnelle, une apoptose et/ou une expression eNOS.

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