Neuroprotective effective compound

A - Human Necessities – 61 – K

Patent

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Details

A61K 48/00 (2006.01)

Patent

CA 2613551

The present application discloses a method of preventing degeneration of nerve, which includes: a) generating a recombinant viral or plasmid vector comprising a DNA sequence encoding a member of a transforming growth factor superfamily or neurotrophic factor proteins operatively linked to a promoter; b) transfecting in vitro a population o cultured cells with the recombinant vector, resulting in a population of the cultured cells; and c) transplanting the transfected cells to an area near an injured nerve, such that expression of the DNA sequence within the area near the injured nerve causes prevention o degeneration of the nerve.

L'invention concerne un procédé destiné à la prévention de la dégénérescence des nerfs, procédé comprenant les étapes suivantes : a) génération d'un vecteur viral ou plasmide recombinant comprenant une séquence ADN codant un élément d'une superfamille de croissance transformant ou des protéines d'un facteur neurotrophique liées coopérantes à un promoteur ; b) transfection in vitro d'une population de cellules cultivées avec le vecteur recombinant, conduisant à l'obtention d'une population de cellules cultivées ; et c) transplantation des cellules transfectées en une aire voisine du nerf lésé, de sorte que l'expression de la séquence ADN dans ladite aire voisine du nerf lésé entraîne la prévention de la dégénérescence du nerf.

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