Neuroprotective modulation of nmda receptor subtype activities

Details Neuroprotective modulation of nmda receptor subtype activities Neuroprotective modulation of nmda receptor subtype activities

A - Human Necessities

61

K

A61K 31/445 (2006.01) A61K 31/155 (2006.01) A61K 31/223 (2006.01) A61K 31/4164 (2006.01) A61K 31/436 (2006.01) A61P 25/00 (2006.01)

Patent

CA 2615147

In various aspects, the invention provides methods and compositions for modulating NMDA receptor subtype activity, to enhance NR2A-containing NMDA receptor activity relative to NR2B- containing NMDA receptor activity, so as to effect a neuroprotective reduction in excitotoxic NMDA receptor activity.

Dans divers aspects, l'invention concerne des méthodes et des compositions qui permettent de moduler l'activité du sous-type du récepteur NMDA afin d'améliorer l'activité du récepteur NMDA contenant NR2A par rapport à l'activité du récepteur NMDA contenant NR2B de façon à entraîner une réduction neuroprotectrice de l'activité du récepteur NMDA excitotoxique.

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