Neuroprotective multifunctional compounds and pharmaceutical...

Details Neuroprotective multifunctional compounds and pharmaceutical... Neuroprotective multifunctional compounds and pharmaceutical...

C - Chemistry, Metallurgy

07

C

C07C 211/38 (2006.01) A61K 31/131 (2006.01) A61K 31/135 (2006.01) A61K 31/47 (2006.01) A61P 9/00 (2006.01) A61P 25/00 (2006.01) A61P 29/00 (2006.01) C07C 259/10 (2006.01) C07C 271/40 (2006.01) C07D 215/34 (2006.01) C07D 401/12 (2006.01)

Patent

CA 2751033

Multifunctional compounds are provided, comprising two or more functional moieties selected from: (i) a moiety that imparts an iron chelator function; (ii) a moiety that imparts a neuroprotective function; (iii) a moiety that imparts combined antiapoptotic, neuroprotective and/or neurorestorative functions; (iv) a moiety that imparts brain MAO inhibition, preferably with little or no MAO inhibition in liver and small intestine; (v) a moiety that imparts cholinesterase inhibitory function; and (vi) a moiety that imparts an N-methyl-D-aspartic acid receptor (NMDAR) inhibition, and pharmaceutically acceptable salts and optical isomers thereof. The multifunctional compounds are useful in the treatment or prevention of diseases, disorders or conditions that can be prevented and/or treated by iron chelation therapy, and/or neuroprotection and/or neurorestoration, and/or apoptosis inhibition and/or MAO inhibition and/or cholinesterase inhibition and/or NMADR inhibition. The present invention encompasses compounds of the formulas I to V1.

La présente invention concerne des composés qui comprennent deux fractions fonctionnelles ou plus, choisies parmi : (i) une fraction qui impartit une fonction de chélation du fer; (ii) une fraction qui impartit une fonction de neuroprotection; (iii) une fraction qui impartit une combinaison de fonctions anti-apoptotiques, de neuroprotection et/ou de neurorestauration; (iv) une fraction qui impartit l'inhibition de la MAO cérébrale, de préférence avec une inhibition faible ou inexistante de la MAO dans le foie et l'intestin grêle; (v) une fraction qui impartit une fonction d'inhibition de la cholinestérase; et (vi) une fraction qui impartit l'inhibition des récepteurs de l'acide N-méthyl-D-aspartique (NMDAR), et des sels pharmaceutiquement acceptables ainsi que des isomères optiques de ceux-ci. Les composés multifonctionnels sont utiles dans le traitement ou la prévention de maladies, de troubles ou de conditions qui peuvent être empêchés et/ou traités par une thérapie par chélation du fer, et/ou par neuroprotection et/ou par neurorestauration, et/ou par inhibition de l'apoptose et/ou par inhibition de la MAO et/ou par inhibition de la cholinestérase et/ou par inhibition des NMDAR.

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