C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/19 (2006.01) A01K 67/027 (2006.01) A61K 31/70 (2006.01) A61K 38/19 (2006.01) A61K 39/395 (2006.01) A61K 48/00 (2006.01) C07K 14/52 (2006.01) C07K 16/24 (2006.01) C07K 19/00 (2006.01) C12N 9/96 (2006.01) C12N 15/11 (2006.01) C12N 15/62 (2006.01) C12Q 1/68 (2006.01) G01N 33/68 (2006.01)
Patent
CA 2253864
The present invention relates to the identification and characterization of a novel, membrane-anchored chemokine, neurotactin. Sequence analysis of neurotactin reveals that, while it includes an amino terminal domain which resembles that of other chemokines, it has an overall structure which distinguishes it from all presently identified chemokines. Neurotacting is highly expressed in normal mammalian brain.
Cette invention a trait à l'identification ainsi qu'à la caractérisation d'une nouvelle chémokine à ancrage membranaire, la neurotactine. Une analyse séquentielle de la neurotactine fait apparaître que tout en comportant un domaine aminé terminal ressemblant à celui d'autres chémokines, elle possède une structure d'ensemble qui la distingue de toutes les chémokines recensées jusqu'ici. La neurotactine est très exprimée dans le cerveau des mammifères.
Marks & Clerk
Millennium Biotherapeutics Inc.
Millennium Pharmaceuticals Inc.
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