Neurotoxins with enhanced target specificity

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 9/52 (2006.01) C07K 14/33 (2006.01) C12N 15/31 (2006.01) C12N 15/57 (2006.01) C12N 15/63 (2006.01) A61K 38/48 (2006.01)

Patent

CA 2430365

Modified neurotoxins that contain protease cleavage sites susceptible uniquely to proteases present in certain tissues are described. The toxins can be selectively activated by protease in muscle or selectively inactivated by proteases in blood.

L'invention concerne des neurotoxines modifiées contenant des sites de clivage de protéase sensibles uniquement aux protéases présentes dans certains tissus. Ces toxines peuvent être activées de manière sélective par les protéases du muscle, ou inactivées de manière sélective par les protéases du sang.

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