Neurotransmitter release enhancers

Details Neurotransmitter release enhancers Neurotransmitter release enhancers

C - Chemistry, Metallurgy

07

D

C07D 401/14 (2006.01) A61K 31/40 (2006.01) A61K 31/41 (2006.01) A61K 31/44 (2006.01) A61K 31/495 (2006.01) C07C 233/06 (2006.01) C07D 213/20 (2006.01) C07D 213/54 (2006.01) C07D 239/26 (2006.01) C07D 401/06 (2006.01) C07D 405/06 (2006.01) C07D 405/14 (2006.01) C07D 409/14 (2006.01) C07D 413/06 (2006.01) C07D 417/14 (2006.01)

Patent

CA 2188427

This invention relates to compounds of formula (IA), (IB), (IC) or (ID), wherein m, X, Z, R2, R3, R4, R5, R6, R14 and the dotted lines are as defined below, their pharmaceutically acceptable salts, pharmaceutical compositions containing them and methods of using them to neat Alzheimer's disease, age-associated memory impairment, Parkinson's disease and other central nervous system disorders. The claimed compounds have the ability to enhance the release of neurotransmitters such as acetylcholine, dopamine and serotonin.

Cette invention se rapporte à des composés des formules (IA, IB, IC, ID) dans lesquelles m, X, Z, R?2¿, R?3¿, R?4¿, R?5¿, R?6¿, R?14¿ et les lignes en pointillés sont tels que définis ci-dessous, à leurs sels pharmaceutiquement acceptables, à des compositions pharmaceutiques les contenant et à leurs procédés d'utilisation dans le traitement de la maladie d'Alzheimer, de l'altération de la mémoire due à l'âge, de la maladie de Parkinson et d'autres troubles du système nerveux central. Les composés revendiqués ont le pouvoir de stimuler la libération des neurotransmetteurs, tels que l'acétylcholine, la dopamine et la sérotonine.

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