Neurotrophic and antiproliferative compounds

Details Neurotrophic and antiproliferative compounds Neurotrophic and antiproliferative compounds

C - Chemistry, Metallurgy

07

C

C07C 57/00 (2006.01) A61K 31/19 (2006.01) A61K 31/33 (2006.01) C07C 51/38 (2006.01) C07C 53/126 (2006.01) C07C 53/128 (2006.01) C07C 57/02 (2006.01) C07C 57/03 (2006.01) C07C 57/18 (2006.01)

Patent

CA 2198728

Neurotrophic and antiproliferative compounds related to the antiepileptic drug valproate of general formula (I), wherein R1 is -CCH, -CH=CH2 or -CH2-CH3, R2 is a saturated, unsaturated, branched or unbranched C1-C30 alkyl group which is optionally substituted with a C3-C9 aliphatic or aromatic cyclohydrocarbon,or heterocyclic group. M is a hydrogen or a metal atom. Formula (I) is not 2-n-propyl-4-pentynoic acid (4-yn-VPA) or 2-n-propyl-4- pentenoic acid (4-en-VPA) and when R1 is -CH2-CH3, R2 is C5 to C30. This invention also provides a method of making the compounds of the invention. The compounds are useful for promoting neuronal function as in neurodegenerative disorders and for treating neoplastic disease.

L'invention concerne des composés neurotrophiques et antiprolifératifs, se rapportant à l'antiépileptique valproate, de formule générale (I), où R?1¿ représente -C?CH, -CH=CH¿2? ou -CH¿2?-CH¿3?; R?2¿ représente un groupe alkyle C¿1?-C¿30? saturé, non saturé, ramifié ou non; éventuellement substitué par un groupe C¿3?-C¿9? d'hydrocarbure cyclique aromatique ou aliphatique, ou hétérocyclique; M représente un atome d'hydrogène ou de métal. La formule (I) n'est pas un acide 2-n-propyl-4-pentynoïque (4-yn-VPA) ni un acide 2-n-propyl-4-penténoïque (4-en-VPA) et lorsque R?1¿ représente -CH¿2?-CH¿3?, R?2¿ représente C¿5? à C¿30?. L'invention concerne également un procédé de fabrication desdits composés. Ces composés sont utilisés afin de stimuler la fonction neuronale dans les maladies neurodégénératives et afin de traiter les maladies néoplasiques.

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