Neurotrophic and neuroprotective peptides

C - Chemistry – Metallurgy – 07 – K

Patent

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Details

C07K 7/00 (2006.01) C07K 5/06 (2006.01) C07K 5/083 (2006.01) C07K 5/093 (2006.01) C07K 5/103 (2006.01) C07K 5/11 (2006.01) C07K 5/113 (2006.01) C07K 14/47 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2480633

The invention relates to novel peptides, whose individual components are L- amino acids or D-amino acids. Said peptides are used as active ingredients in medicaments for treating diseases in which the increased occurrence of free radicals plays a pathophysiological role, or for treating diseases involving acute hypoxia or ischaemia in an organ system of the body, in particular in the central nervous system, or for treating iron-storage diseases such as Hallervorden-Spatz syndrome, or for treating neurodegenerative diseases, in particular Alzheimer's disease, the Lewy body variant of Alzheimer's disease, Parkinson's disease, multi-system atrophy, Lewy body dementia or Huntington's chorea and all syndromes that are similar to said neurodegenerative diseases.

L'invention concerne de nouveaux peptides dont les composants individuels sont des L-aminoacides ou des D-aminoacides. Ces peptides sont utilisés en tant que principes actifs dans des médicaments pour le traitement de maladies dans lesquelles l'augmentation de l'apparition de radicaux libres joue un rôle pathophysiologique, ou bien pour le traitement de maladies impliquant une hypoxie aiguë ou une ischémie dans un système organique du corps, en particulier dans le système nerveux central, ou pour le traitement de maladies liées au stockage du fer telles que la maladie de Hallervorden-Spatz, ou bien pour le traitement de maladies neurodégénératives, en particulier de la maladie d'Alzheimer, de la variante à corps de Lewy de la maladie d'Alzheimer, de la maladie de Parkinson, de l'atrophie multisystémique, de la démence à corps de Lewy, de la chorée de Huntington, et de tous les syndromes similaires auxdites maladies dégénératives.

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