C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 207/08 (2006.01) A61K 31/40 (2006.01) A61K 31/445 (2006.01) C07D 211/10 (2006.01) C07D 401/12 (2006.01) C07D 403/12 (2006.01)
Patent
CA 2350429
The present invention relates to the design, synthesis, and the peptidyl- prolyl isomerase (PPIase or rotamase) inhibitory activity of novel pyrrolidinemethyl diamide and carbamate compounds that are neurotrophic agents (i.e. compounds capable of stimulating growth or proliferation of nervous tissue) and that bind to immunophilins such as FKBP12 and inhibit their rotamase activity. This invention also relates to pharmaceutical compositions comprising these compounds.
La présente invention porte sur la formation, la synthèse et l'activité inhibitrice de peptidyl-prolyl isomérase (PPIase ou rotamase) de nouveaux composés pyrrolidineméthyl de diamide et de carbamate qui sont des agents neutrophiques (c.-à-d. des composés capables de stimuler la croissance ou la prolifération du tissu nerveux) et qui se fixent aux immunophilines telles que FKBP12 et inhibent l'activité de leur rotamase. Cette invention porte également sur des compositions pharmaceutiques comprenant ces composés.
Denhart Derek J.
Ditta Jonathan L.
Dubowchik Gene M.
Provencal David P.
Bristol-Myers Squibb Company
Gowling Lafleur Henderson Llp
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