C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 211/68 (2006.01) A61K 31/34 (2006.01) A61K 31/40 (2006.01) A61K 31/44 (2006.01) A61K 31/4439 (2006.01) A61K 31/445 (2006.01) A61K 31/4545 (2006.01) A61P 25/00 (2006.01) C07D 207/06 (2006.01) C07D 207/12 (2006.01) C07D 207/16 (2006.01) C07D 211/60 (2006.01) C07D 401/12 (2006.01)
Patent
CA 2333997
The present invention relates to the design, synthesis, and the peptidyl- prolyl isomerase (PPIase or rotamase) inhibitory activity of novel .alpha.,.alpha.-difluoroacetamido compounds that are neurotrophic agents (i.e. compounds capable of stimulating growth or proliferation of nervous tissue) and that bind to immunophilins such as FKBP12 and inhibit their rotamase activity. This invention also relates to pharmaceutical compositions comprising these compounds.
La présente invention concerne la conception, la synthèse et l'activité inhibitrice de peptidyl-prolyle isomérase (PPIase ou rotamase) de nouveaux composés .alpha.,.alpha.-difluoroacétamido constituant des agents neurotrophiques (c.-à-d. des composés capables de stimuler la croissance ou la prolifération de tissus nerveux) se liant à des immunophilines telles que FKBP12 et inhibant leur activité rotamase. La présente invention concerne également des compositions pharmaceutiques contenant ces composés.
Dasgupta Bireshwar
Dubowchik Gene M.
Vrudhula Vivekananda M.
Vyas Dolatrai M.
Bristol-Myers Squibb Company
Gowling Lafleur Henderson Llp
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