Neurotrophic factor manf and uses thereof

Details Neurotrophic factor manf and uses thereof Neurotrophic factor manf and uses thereof

C - Chemistry, Metallurgy

07

K

C07K 14/475 (2006.01) A61K 38/18 (2006.01) A61K 48/00 (2006.01) A61P 25/00 (2006.01) A61P 25/16 (2006.01) C12N 15/12 (2006.01)

Patent

CA 2725128

The present invention generally relates to the field of treatment of neuronal disorders and more particularly to neurotrophic factor MANF and uses thereof. The present invention provides a pharmaceutical compound comprising MANF nucleic acid molecule, MANF protein or a functional fragment thereof for the treatment of a peripherial neuropathy including Alzheimer's disease, Parkinson's disease, epilepsy, drug addiction and ischemic brain injury.

Dune façon générale, la présente invention concerne le domaine du traitement de troubles neuronaux et, plus particulièrement, le facteur neurotrophique MANF et sur des utilisations de celui-ci. La présente invention porte sur un composé pharmaceutique qui renferme une molécule d'acide nucléique de MANF, une protéine MANF ou un fragment fonctionnel de ceux-ci et peut être utilisé dans le traitement d'une neuropathie périphérique dont la maladie d'Alzheimer, la maladie de Parkinson, l'épilepsie, la toxicomanie et une lésion cérébrale ischémique.

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