Neurotrophic factor production accelerator

A - Human Necessities – 61 – K

Patent

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Details

A61K 31/495 (2006.01) A61K 38/48 (2006.01) A61K 45/00 (2006.01) A61P 25/00 (2006.01) A61P 25/02 (2006.01) A61P 25/04 (2006.01) A61P 25/14 (2006.01) A61P 43/00 (2006.01) C07D 295/22 (2006.01) C07D 295/32 (2006.01)

Patent

CA 2481970

A neurotrophic factor production accelerator which contains as an active ingredient a compound represented by the following formula (I): (I) [wherein R1 represents a lower alkyl, aryl, ar(lower)alkoxy, or heterocyclic group which has been optionally substituted by a halogen; R2 represents hydrogen or lower alkyl; R3 represents a cyclo(lower)alkyl, aryl, or ar(lower)alkyl group which has been optionally substituted by a halogen; A represents -CO-, -SO2-, or lower alkylene; X represents nitrogen or CH; and Y represents -CO-, -SO2-, or -CONH-] or a salt, prodrug, or solvate of the compound. The neurotrophic factor production accelerator is useful for the prevention of and/or treatments for motor nerve and peripheral nerve diseases.

L'invention concerne un accélérateur de production d'un facteur neurotrophique contenant, comme ingrédient actif, un composé de formule (I), dans laquelle R?1¿ représente un groupe alkyle inférieur, aryle, ar-alcoxy(inférieur) ou hétérocyclique, éventuellement substitué par un halogène ; R?2¿ représente un hydrogène ou un alkyle inférieur ; R?3¿ représente un groupe cycloalkyle(inférieur), aryle ou ar-alkyle(inférieur), éventuellement substitué par un halogène ; A représente CO -, -SO¿2? -, ou un alkylène inférieur ; X représente l'azote ou CH ; et Y représente CO -, - SO¿2? -, ou CONH -, ou un sel, un promédicament ou un solvate de ce composé. L'accélérateur de production d'un facteur neurotrophique est utilisé pour la prévention et/ou le traitement des nerfs moteurs et de maladies nerveuses périphériques.

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