Neurotrophic factors having altered receptor binding...

Details Neurotrophic factors having altered receptor binding... Neurotrophic factors having altered receptor binding...

C - Chemistry, Metallurgy

07

K

C07K 14/48 (2006.01) C07K 14/475 (2006.01) G01N 33/566 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2131552

2131552 9318066 PCTABS00025 A method of altering the receptor binding properties and the stability of neurotrophic factors is set forth. Mutant neurotrophic factors having altered receptor binding specificities are described. Specific embodiments include neurotrophic factors that bind trk receptors but do not bind to the low affinity NGF receptor.

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