C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 14/475 (2006.01) A61K 38/08 (2006.01) A61K 38/10 (2006.01) A61K 38/18 (2006.01) C07K 7/06 (2006.01) C07K 7/08 (2006.01) C12N 5/06 (2006.01) C12N 5/08 (2006.01)
Patent
CA 2202496
The present invention relates generally to Activity Dependent Neurotrophic Factor (ADNF). More particularly, the present invention relates to a family of polypeptides derived from ADNF that exhibit neuroprotective/neurotrophic action on neurons originating in the central nervous system and to uses thereof for the treatment of neurological deficiencies and for the prevention of cell death. The present invention also relates to pharmaceutical compositions designed to prevent neuronal cell death.
L'invention concerne généralement le facteur neurotrophique dépendant de l'activité et, plus particulièrement, une famille de polypeptides dérivés dudit facteur et présentant une action neuroprotectrice/neurotrophique sur les neurones prenant naissance dans le système nerveux central. Elle porte aussi sur les utilisations dudit facteur pour le traitement de déficiences neurologiques et la prévention de la mort cellulaire, ainsi que sur des compositions pharmaceutiques conçues pour prévenir la mort cellulaire neuronale.
Brenneman Douglas E.
Gozes Illana
Fetherstonhaugh & Co.
Ramot University Authority For Applied Research And Industrial D Ltd.
The Government Of The United States Of America As Represented By The Se Cretary Of The Department Of Health And
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