Neurotrophin-3-deficient embryonic stem cell and its use

Details Neurotrophin-3-deficient embryonic stem cell and its use Neurotrophin-3-deficient embryonic stem cell and its use

C - Chemistry, Metallurgy

12

N

C12N 5/10 (2006.01) A01K 67/027 (2006.01) C12N 15/85 (2006.01) C12Q 1/34 (2006.01) C12Q 1/68 (2006.01) G01N 33/48 (2006.01)

Patent

CA 2127412

Abstract The present invention provides non-human mammalian NT-3 deficient embryonic stem cell and a non-human NT-3 deficient mammal generated using the cell. The non-human mammal of the present invention is useful as an animal model in elucidating the function of NT-3 in vivo or in investigating various lesions associated with functional disorder of NT-3. The present invention also provides a method of screening a substance capable of enhancing NT-3 promoter using the non-human mammal.

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