Neurturin and related growth factors

Details Neurturin and related growth factors Neurturin and related growth factors

C - Chemistry, Metallurgy

12

N

C12N 15/18 (2006.01) A61K 38/18 (2006.01) A61K 48/00 (2006.01) C07K 14/475 (2006.01) C07K 14/48 (2006.01) C07K 19/00 (2006.01) C12N 5/10 (2006.01) C12N 15/62 (2006.01) C12N 15/63 (2006.01)

Patent

CA 2194172

A novel growth factor, neurturin, is disclosed and the human and mouse amino acid sequences are identified. Human and mouse neurturin genomic DNA sequences have been cloned and sequenced and the respective cDNA sequences identified. The subcloning into vectors and the preparation of cells stably transformed with the vectors are also disclosed. In addition, methods for treating degenerative conditions, tumor cells and obesity; methods for detecting gene alterations and methods for detecting and monitoring patient levels of neurturin are provided. Methods for identifying additional members of the neurturin-GDNF family of growth factors are also provided.

L'invention porte sur un nouveau facteur de croissance, nommé neurturin, ainsi que sur l'identification des séquences d'acides aminés chez l'homme et la souris. On a cloné et séquencé des séquences d'ADN génomique de neurturin chez l'homme et la souris et identifié les séquences d'ADN complémentaire respectives. L'invention, qui porte sur un clonage complémentaire en vecteurs ainsi que sur la production de cellules transformées de façon stable par lesdits vecteurs, concerne également des méthodes de traitement de pathologies dégénératives, de l'obésité et de cellules tumorales, des procédés de détection de modifications de gène ainsi que de détection et de surveillance de taux de neurturin chez un patient et, enfin, des procédés permettant l'identification d'éléments complémentaires de la famille GDNF-neurturin (facteur neurotrophique dérivé de la cellule gliale) des facteurs de croissance.

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