C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/87 (2006.01) A61K 9/10 (2006.01) A61K 48/00 (2006.01) C12N 15/10 (2006.01) C12N 15/88 (2006.01)
Patent
CA 2429803
Processes for making neutral or anionic complexes containing sequestered DNA for gene transfer, by forming a stable colloid containing an aqueous phase having suspended therein a first DNA complex with a cationic surface potential comprising a DNA sequence complexed with a cationic lipid or polymer, and modifying the surface potential of the first DNA complex to form a stable colloid comprising a second DNA complex with a neutral or net anionic surface potential.
L'invention concerne des procédés permettant de produire des complexes neutres ou anioniques contenant de l'ADN séquestré pour le transfert de gènes. Ces procédés consistent à former un colloïde stable contenant une phase aqueuse qui comprend en suspension un premier complexe d'ADN présentant un potentiel de surface cationique, ce premier complexe comprenant une séquence d'ADN complexée avec un polymère ou un lipide cationique, puis à modifier le potentiel de surface du premier complexe d'ADN de façon à obtenir un colloïde stable comprenant un second complexe d'ADN présentant un potentiel de surface neutre ou anionique nette.
Hofland Hans
Lamons Donald
Meng Xiao-Ying
Centelion
Gencell S.a.
Robic
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