A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 39/395 (2006.01) A61P 35/00 (2006.01) C07K 16/28 (2006.01) G01N 33/566 (2006.01)
Patent
CA 2673868
The present invention relates to methods for treating an individual with high grade glioblastoma multiforme by preventing or disrupting the binding of CD95 to its ligand, CD95L, in vivo, whereupon that neutralization of CD95 activity reduces undesirable glial cell migration and invasion into body tissue.
L'invention concerne des procédés qui permettent de traiter un individu atteint d'un glioblastome multiforme bien différencié en empêchant ou en interrompant la liaison de CD95 à son ligand, CD95L, in vivo, cette neutralisation de l'activité de CD95 réduisant la migration des cellules gliales indésirables et l'invasion des tissus corporels par ces dernières.
Herold-Mende Christel
Kleber Susanne
Krammer Peter G.
Martin-Villalba Ana
Sancho-Martinez Ignacio
Deutsches Krebsforschungszentrum Stiftung Des Oeffentlichen Rech
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
Universitaetsklinikum Heidelberg
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