Neutralizing and/or adcc mediating monoclonal hiv antibody

C - Chemistry – Metallurgy – 12 – P

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C12P 21/08 (2006.01) A61K 39/40 (2006.01) C07K 14/16 (2006.01) C07K 16/10 (2006.01) C12N 5/18 (2006.01) G01N 33/569 (2006.01) G01N 33/577 (2006.01) A61K 39/00 (2006.01)

Patent

CA 2073963

2073963 9111198 PCTABS00006 Monoclonal antibodies (MAbs) to human immunodeficiency virus (HIV) mediating neutralization of HIV and/or antibody-dependant cellular cytotoxity to HIV, a method to prepare these MAbs and hybridomas producing these MAbs are disclosed. The MAbs have utility i.a. in preventing spread of HIV infections, as a passive or active vaccine, for assay of HIV antigens, and to identify a neutralizing epitope in preparations for immunization.

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