C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 16/24 (2006.01) A61K 39/395 (2006.01)
Patent
CA 2687791
The present invention provides antibodies that bind, interact or otherwise associate with GM-CSF or a fragment, portion or part thereof and antagonize or neutralize GM-CSF activity. In accordance with embodiments of the present invention humanized monoclonal antibodies are generated which bind to human GM-CSF with high affinity and which inhibit the activity of GM-CSF.
La présente invention concerne des anticorps qui se lient, interagissent ou s'associent d'une autre manière avec GM-CSF ou un fragment, une portion ou une partie de GM-CSF et antagonisent ou neutralisent l'activité de GM-CSF. Selon certains modes de réalisation de la présente invention, des anticorps monoclonaux humanisés sont générés. Ces anticorps monoclonaux humanisés se lient au GM-CSF humain avec une grande affinité et inhibent l'activité de GM-CSF.
Mackay Charles
Zahra David
Crc For Asthma And Airways Ltd
Gowling Lafleur Henderson Llp
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