Neutralizing antibodies against gdf-8 and uses therefor

Details Neutralizing antibodies against gdf-8 and uses therefor Neutralizing antibodies against gdf-8 and uses therefor

C - Chemistry, Metallurgy

12

N

C12N 15/13 (2006.01) A61K 39/395 (2006.01) A61P 3/00 (2006.01) A61P 21/00 (2006.01) C07K 16/22 (2006.01) C12N 1/21 (2006.01) C12P 21/02 (2006.01) G01N 33/53 (2006.01)

Patent

CA 2500490

The disclosure provides novel antibodies against growth and differentiation factor-8 (GDF-8), in particular human antibodies, and antibody fragments, including those that inhibit GDF-8 activity in vitro and/or in vivo. The disclosure also provides methods for diagnosing, preventing, or treating degenerative disorders of muscle or bone, or disorders of insulin metabolism.

L'invention concerne de nouveaux anticorps dirigés contre le facteur de croissance et de différenciation 8 (GDF-8), en particulier des anticorps humains, et des fragments d'anticorps, y compris ceux qui inhibent l'activité de GDF-8 in vitro et/ou in vivo. L'invention concerne aussi des méthodes permettant de diagnostiquer, de prévenir ou de traiter des troubles dégénératifs des muscles ou des os, ou des troubles du métabolisme de l'insuline.

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