C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 16/28 (2006.01) A61K 38/17 (2006.01) A61K 39/395 (2006.01) A61P 11/06 (2006.01) A61P 19/02 (2006.01) A61P 31/00 (2006.01) A61P 37/00 (2006.01) C07K 19/00 (2006.01) C12N 5/10 (2006.01) C12N 15/79 (2006.01) G01N 33/50 (2006.01)
Patent
CA 2548990
This invention provides monoclonal antibodies that recognize the Toll-like Receptor 4/MD-2 receptor complex, and monoclonal antibodies that recognize the TLR4/MD2 complex as well as TLR4 when not complexed with MD-2. The invention further provides methods of using the monoclonal antibodies as therapeutics. This invention also provides soluble chimeric proteins, methods of expressing and purifying soluble chimeric proteins, and methods of using soluble chimeric proteins as therapeutics, in screening assays and in the production of antibodies.
La présente invention a trait à des anticorps monoclonaux d'identification de complexe récepteur 4/MD-2 du récepteur Toll, et des anticorps monoclonaux d'identification du complexe TLR4/MD2 ainsi que le TLR4 lorsqu'il n'est pas en complexe avec MD-2. L'invention a également trait à des procédés d'utilisation des anticorps comme agents thérapeutiques. L'invention a trait en outre à des protéine chimériques solubles, des procédés d'expression et de purification de protéines chimériques solubles, et des procédés d'utilisation de protéines chimériques solubles comme agents thérapeutiques, dans des dosages de criblage et dans la production d'anticorps.
Novimmune Sa
Ridout & Maybee Llp
LandOfFree
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