Neutralizing antibodies to influenza viruses

Details Neutralizing antibodies to influenza viruses Neutralizing antibodies to influenza viruses

C - Chemistry, Metallurgy

07

K

C07K 16/10 (2006.01) A61K 39/42 (2006.01) A61P 31/16 (2006.01) C12Q 1/68 (2006.01) G01N 33/68 (2006.01)

Patent

CA 2652452

The present invention concerns methods and means for identifying, producing, and engineering neutralizing antibodies against influenza A viruses, and to the neutralizing antibodies produced. In particular, the invention concerns neutralizing antibodies against various influenza A virus subtypes, including neutralizing antibodies against two or more of Hl, H2, H3, H5, H7 and H9, such as, for example all of Hl, H2, H3, and H5 subtypes, and methods and means for making such antibodies. More specifically, the invention concerns antibodies capable of neutralizing more than one, preferably all, isolates of an influenza A virus subtype.

La présente invention concerne des procédés et des moyens pour identifier, produire et synthétiser des anticorps neutralisants contre les virus de la grippe A, et les anticorps neutralisants obtenus. En particulier, l'invention concerne des anticorps neutralisants dirigés contre divers sous-types des virus de la grippe A, comprenant les anticorps neutralisants dirigés contre deux ou plus parmi H1, H2, H3, H5, H7 et H9, tels que, par exemple, la totalité des sous-types H1, H2, H3 et H5, et des procédés et des moyens pour fabriquer de tels anticorps. Plus spécifiquement, l'invention concerne des anticorps capables de neutraliser plus d'un isolat, de préférence tous les isolats d'un sous-type des virus de la grippe A.

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