C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 7/00 (2006.01) A61K 39/12 (2006.01) C07K 1/00 (2006.01) C12N 1/20 (2006.01) C12N 7/04 (2006.01) C12N 15/09 (2006.01) C12Q 1/68 (2006.01) C12Q 1/70 (2006.01) G01N 33/53 (2006.01)
Patent
CA 2355883
Pseudovirions, comprised of a papilloma virus-like particle (VLP) joined to a reporter gene construct are described. The pseudovirions can be used in assays to detect the presence of anti-VLP neutralizing antibodies. Also described are processes for making the pseudovirions.
L'invention concerne des pseudovirions comprenant une particule vériforme du papillomavirus liée à une structure de gène rapporteur. Les pseudovirions peuvent être utilisés dans des dosages pour détecter la présence d'anticorps neutralisants dirigés contre les particules vériformes. L'invention concerne aussi des processus de fabrication de ces pseudovirions.
Aste-Amezaga Miguel
Jansen Kathrin U.
Keller Paul M.
Lowe Robert S.
Yeager Mark D.
Gowling Lafleur Henderson Llp
Merck & Co. Inc.
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