Neutralizing human monoclonal antibodies against hiv-1,...

Details Neutralizing human monoclonal antibodies against hiv-1,... Neutralizing human monoclonal antibodies against hiv-1,...

C - Chemistry, Metallurgy

07

K

C07K 16/00 (2006.01) C07K 16/10 (2006.01) C12N 15/85 (2006.01)

Patent

CA 2436091

The present invention relates to a novel human antibody, and antigen-binding portion thereof, that specifically binds HIV-1 gp120 protein and that has HIV- 1- neutralizing activity. The present invention also relates to a cell line that produces an antibody of this invention. The present invention further relates to a pharmaceutical composition or a kit comprising an antibody or antigen binding portion thereof of this invention. The present invention further relates to a method of using the antibody of this invention to treat a subject with an HIV-1 infection or prevent a subject from getting an HIV-1 infection. The present invention also relates to a novel method of making an antibody of this invention. The method involves using a non-human transgenic animal. The present invention further relates to methods of identifying regions of gp120 for use as HIV-1 vaccine.

L'invention concerne un nouveau anticorps humain, et une partie de liaison d'antigène de celui-ci, qui se lie spécifiquement à la protéine VIH-1 gp120 et qui possède une activité de neutralisation du VIH-1. L'invention concerne également une lignée cellulaire produisant l'anticorps de l'invention. Elle concerne une composition pharmaceutique ou un kit comprenant un anticorps ou une partie de liaison d'antigène de celui-ci. Elle concerne une méthode d'utilisation de l'anticorps pour traiter un sujet souffrant d'une infection par le VIH -1 ou pour empêcher ledit sujet d'attraper une infection par le VIH-1. Elle concerne une nouvelle méthode de production d'anticorps. Elle implique l'utilisation d'un animal transgénique non humain. Elle concerne des méthodes permettant d'identifier des régions de gp120 utilisées comme vaccin contre le VIH-1.

Affiliated with

Also associated with

Rating

Neutralizing human monoclonal antibodies against hiv-1,... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Neutralizing human monoclonal antibodies against hiv-1,..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Neutralizing human monoclonal antibodies against hiv-1,... will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1914640