C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 16/28 (2006.01) A61K 39/395 (2006.01) A61P 25/00 (2006.01) C12N 5/16 (2006.01) C12N 15/13 (2006.01) C12P 21/08 (2006.01) C07K 14/705 (2006.01)
Patent
CA 2670368
The subject invention relates to isolated proteins, particularly monoclonal antibodies, which bind to the Nogo-66 receptor. Specifically, these antibodies have the ability to inhibit the binding of the natural ligand of the Nogo-66 receptor and neutralize the Nogo-66 receptor. These antibodies or portions thereof of the invention are useful for detecting NgR and for inhibiting NgR activity, for example in a human suffering from a disorder in which NgR or Nogo-66 activity is detrimental.
La présente invention concerne des protéines isolées, notamment des anticorps monoclonaux qui se lient au récepteur Nogo-66. Les anticorps présentent spécifiquement la capacité d'inhiber la liaison au ligand naturel du récepteur Nogo-66 et de neutraliser le récepteur Nogo-66. Les anticorps de l'invention, dans leur intégralité ou en parties, sont utiles pour détecter le NgR et inhiber l'activité du NgR chez un humain souffrant d'un trouble dans lequel l'activité du NgR ou du Nogo-66 est nuisible, par exemple.
Barlow Eve H.
Ghayur Tariq
Meyer Axel
Mezler Mario
Moeller Achim
Abbott Gmbh & Co. Kg
Abbott Laboratories
Torys Llp
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