Neutralizing proprotein convertase subtilisin kexin type 9...

Details Neutralizing proprotein convertase subtilisin kexin type 9... Neutralizing proprotein convertase subtilisin kexin type 9...

A - Human Necessities

61

K

A61K 38/48 (2006.01) A61P 3/06 (2006.01) C12N 9/64 (2006.01)

Patent

CA 2720681

Neutralizing PCSK9 variants that interact with low density lipoprotein receptor (LDLR) are described. Methods and compositions for treating disorders by administering a pharmaceutically effective amount of a neutralizing PCSK9 variant are described.

La présente invention concerne des variants neutralisants de la PCSK9 qui interagissent avec un récepteur de lipoprotéines de faible densité (LDLR). Des méthodes et des compositions permettant de traiter des troubles par administration dune quantité pharmaceutiquement efficace dun variant neutralisant de la PCSK9 sont décrites.

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