C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/13 (2006.01) A61K 39/395 (2006.01) A61K 47/48 (2006.01) A61K 49/00 (2006.01) A61P 35/00 (2006.01) A61P 37/00 (2006.01) C07K 14/52 (2006.01) C07K 16/24 (2006.01) C07K 19/00 (2006.01) C12N 5/12 (2006.01) C12N 15/64 (2006.01) G01N 33/554 (2006.01) G01N 33/564 (2006.01) G01N 33/574 (2006.01) G01N 33/60 (2006.01)
Patent
CA 2419661
The present invention relates to nucleic acid molecules encoding Neutrokine- alpha and/or Neutrokine-alphaSV polypeptides, including soluble forms of the extracellular domain. Neutrokine-alpha and/or Neutrokine-alphaSV polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to antibodies or portions thereof that specifically bind Neutrokine-alpha and/or Neutrokine-alphaSV and diagnostic and therapeutic methods using these antibodies. Also provided are diagnostic methods for detecting immune system-related disorders and therapeutic methods for treating immune system-related disorders using the compositions of the invention.
L'invention concerne des molécules d'acide nucléique codant des polypeptides neutrokine-alpha et/ou variant d'épissage de neutrokine-alpha, y compris des formes solubles du domaine extracellulaire. Ces polypeptides sont également fournis ainsi que des vecteurs, cellules hôtes et des procédés de recombinaison permettant de les produire. L'invention concerne également des anticorps ou des parties associées qui lient spécifiquement la neutrokine-alpha et/ou le variant d'épissage de neutrokine-alpha, ainsi que des procédés diagnostiques et thérapeutiques utilisant ces anticorps. Sont également traités des procédés diagnostiques qui permettent de détecter des troubles liés au système immune, ainsi que des procédés thérapeutiques permettant de traiter de tels troubles à l'aide des compositions selon l'invention.
Ebner Reinhard
Ni Jian
Rosen Craig A.
Ullrich Stephen
Yu Guo-Liang
Human Genome Sciences Inc.
Mbm Intellectual Property Law Llp
LandOfFree
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