Neutrophil-activating peptide-2

C - Chemistry – Metallurgy – 12 – P

Patent

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530/7.1, 195/1.3

C12P 21/00 (2006.01) A61K 38/17 (2006.01) C07K 14/47 (2006.01) C07K 14/52 (2006.01) C07K 14/54 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2004685

-26- 118-7405 A B S T R A C T NEUTROPHIL-ACTIVATING PEPTIDE-2 A novel factor is described having neutrophil-stimulating activity and isolated from blood leukocytes and/or platelets. It is structurally and functionally related to neutrophil-activating factor NAF/NAP-1 and is also structurally related to .beta.-thromboglobulin, PBP and CTAP-III. The sequence has been established. The molecular weight of the factor is approximately 6500-7700. 3 variants have also been found. The factor can be prepared fron natural sources or by recombinant DNA techniques.

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