C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 14/47 (2006.01) A61K 38/17 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2089868
47 ABSTRACT OF THE DISCLOSURE A novel human neutrophil adherence-inhibiting substance having the following properties (a) to (g) was identified. (a) It is localized in a platelet granule fraction but released extracellularly in response to a platelet activation stimulus. (b) It has a function to inhibit neutrophil adherence to substrata. (c) It has a function to inhibit neutrophil spreading reaction. (d) Its molecular weight is 2,600 ? 260 kd when measured by gel filtration. (e) Its molecular weight is 340 ? 34 kd and/or 190 ? 19 kd when measured by SDS-PAGE under reducing condition. (f) It is inactivated by trypsin treatment. (g) It contains an amino acid sequence "Pro Glu Arg Glu Gln Xaa Lys" as a part thereof. This substance is useful as an active ingredient of a pharmaceutical composition for the treatment of inflammatory diseases such as rheumatoid arthritis, systemic lupus erythematosus, dermatomyositis, rejection reaction, reperfusion disorder, chronic nephritis, chronic hepatitis, asthma and the like.
Iwabuchi Kazuhisa
Yamashita Tatsuhisa
Iwabuchi Kazuhisa
Mochida Pharmaceutical Co. Ltd.
Smart & Biggar
Yamashita Tatsuhisa
LandOfFree
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