C - Chemistry – Metallurgy – 07 – J
Patent
C - Chemistry, Metallurgy
07
J
C07J 41/00 (2006.01) A61K 31/565 (2006.01)
Patent
CA 2130515
Novel 11-benzaldoxime-estra-diene derivatives of the general Formula I Image and their pharmaceutically-acceptable salts, processes for their production, and pharmaceutical composition containing such compounds, are provided herein. In such compounds of Formula I, Z is -CO-CH3, -CO-0-C2H5, -CO-NH-phenyl, -CO-NH-C2H5, -CO-C2H5, CH3, or -CO-phenyl. Such compounds of the general, Formula I are produced by the esterification or the urethane formation of a compound of the general Formula II with a compound of the general Formula II Image by the reaction of that compound with an esterifying, or an etherifying or an urethane- forming agent which contains the group Z, or its precursor. Such compounds show strong antigestagenic effects combined with reduced glucocorticoid activity.
Elger Walter
Kaufmann Gunther
Kurischko Anatoli
Oettel Michael
Schubert Gerd
Borden Ladner Gervais Llp
Elger Walter
Kaufmann Gunther
Kurischko Anatoli
Oettel Michael
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