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C - Chemistry – Metallurgy – 07 – J

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C07J 41/00 (2006.01) A61K 31/565 (2006.01)

Patent

CA 2130515

Novel 11-benzaldoxime-estra-diene derivatives of the general Formula I Image and their pharmaceutically-acceptable salts, processes for their production, and pharmaceutical composition containing such compounds, are provided herein. In such compounds of Formula I, Z is -CO-CH3, -CO-0-C2H5, -CO-NH-phenyl, -CO-NH-C2H5, -CO-C2H5, CH3, or -CO-phenyl. Such compounds of the general, Formula I are produced by the esterification or the urethane formation of a compound of the general Formula II with a compound of the general Formula II Image by the reaction of that compound with an esterifying, or an etherifying or an urethane- forming agent which contains the group Z, or its precursor. Such compounds show strong antigestagenic effects combined with reduced glucocorticoid activity.

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