A - Human Necessities
61
K
A61K 31/42 (2006.01) C07D 231/12 (2006.01)
Patent
CA 2530175
The invention relates to new N-hydroxy-4-(3-phenyl-5-methyl-isoxazole-4-yl)- benzenesulfonamide solvates of formula (I), wherein n represents 0 or 1 mol, [solvate] represents water, C1-C4 alcohol, Cl-C4 alkylester of C1-C3 carboxylic acid or dioxane, and the mixture of solvated (wherein n=1) and solvat-free forms (wherein n=0). Furthermore, the invention relates their process for production and use for the treatment of osteoarthritis and rheumatoid arthritis and surgical and primary dysmenorrheal pains, based on anti-inflammatory and analgesic pharmacological model experiments.
L'invention concerne de nouveaux solvates de N-hydroxy-4-(3-phényl-5-méthyl-isoxazole-4-yl)-benzènesulfonamide de formule (I), dans laquelle n représente 0 ou 1 mole, [solvate] représente eau, alcool C¿1?-C¿4?, alkylester C¿1?-C¿4? d'acide carboxylique C¿1?-C¿3? ou dioxane et le mélange de formes solvatées (où n = 1) et non solvatées (où n = 0). De plus, l'invention concerne leur procédé de production et d'utilisation pour le traitement de l'ostéoarthrite et de la polyarthrite rhumatoïde et de douleurs chirurgicales et dysménorrhéiques primaires, basé sur des expérimentations de modèles pharmacologiques anti-inflammatoires et analgésiques.
Erdelyi Peter
Fischer Janos
Fodor Tamas
Gere Aniko
Karpati Egon
Fetherstonhaugh & Co.
Richter Gedeon Vegyeszeti Gyar Rt.
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