C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 409/14 (2006.01) A61K 31/445 (2006.01) A61P 25/22 (2006.01) A61P 25/24 (2006.01)
Patent
CA 2355361
Compounds useful for the treatment of disorders of the serotonin-affected neurological systems are provided which have formula (I) wherein: X is carbon or nitrogen; the dotted line represents an optional bond which is absent when X = N; R1 and R2 are each, independently, hydrogen, halogen, CF3, alkyl, alkoxy, or MeSO2; R3 is hydrogen, halogen, or alkyl; R4 is hydrogen, alkyl, alkylaryl, or aryl; and R5 is hydrogen, halogen, CF3, CN, carbamide, or alkoxy; or a pharmaceutically acceptable salt thereof.
L'invention concerne des composés convenant au traitement de troubles du système neurologique liés à la sérotonine, représentés par la formule générale (I) ou l'un de leurs sels pharmaceutiquement admis: Dans cette formule, X représente un carbone ou un azote, le pointillé représente une liaison facultative absente lorsque X=N; R¿1? et R¿2? sont chacun, indépendamment, hydrogène, halogène, CF¿3?, alkyle, alcoxyle, ou MeSO¿2?; R¿3? est hydrogène, halogène, ou alkyle, R¿4? est hydrogène, alkyle, alkylaryle, ou aryle, et R¿5? est hydrogène, halogène, CF¿3?, CN, carbamide, ou alcoxyle.
Baudy Reinhardt Bernhard
Mewshaw Richard Eric
American Home Products Corporation
Smart & Biggar
Wyeth Company
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