New 1,7-annelated 1h-indole-2-carboxylic...

Details New 1,7-annelated 1h-indole-2-carboxylic... New 1,7-annelated 1h-indole-2-carboxylic...

C - Chemistry, Metallurgy

07

D

167/210, 260/239

C07D 471/06 (2006.01) A61K 31/55 (2006.01) C07D 487/06 (2006.01) C07D 498/06 (2006.01) C07D 513/06 (2006.01)

Patent

CA 2011658

Compounds corresponding to the formula I (see above formula) in which R1 represents hydrogen, lower alkyl or cycloalkylalkyl with 4-7 carbon atoms, R2 represents hydrogen, halogen, lower alkyl, lower alkoxy or trifluoromethyl, and R3 represents hydrogen, halogen, lower alkyl or lower alkoxy, or R2 and R3 together denote an alkylenedioxy group, R4 represents cycloalkyl with 5 to 6 carbon atoms, thiophene or optionally substituted phenyl, R5 represents hydrogen or halogen, R6 represents hydrogen, halogen, lower alkyl, lower alkoxy or trifluoromethyl, and Z represents an alkylene chain with 2-4 carbon atoms, which can optionally be mono- or disubstituted by lower alkyl or onto which a 5-6-membered carbocyclic ring can optionally be fused, or represents an -X-CH2-CH2- chain, which have pharmacologically valuable properties, are described, together with a method for their preparation.

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