C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 471/04 (2006.01) A61K 31/437 (2006.01) A61K 31/444 (2006.01) A61K 31/4545 (2006.01) A61P 25/00 (2006.01) C07D 471/14 (2006.01)
Patent
CA 2713997
This disclosure relates to new tricyclic compounds that may be used to modulate a histamine receptor in an individual. Compounds are described, including new 2,3,4,5- tetrahydro-1H- pyrido[4,3-b]indole compounds. Pharmaceutical compositions comprising the compounds are also provided, as are methods of using the compounds in a variety of therapeutic applications, including the treatment of a cognitive disorder, psychotic disorder, neurotransmitter-mediated disorder and/or a neuronal disorder.
La présente invention a trait à des composés tricycliques inédits pouvant être utilisés à des fins de modulation d'un récepteur à l'histamine chez un individu. L'invention a trait, en particulier, à des composés inédits de 2,3,4,5-tétrahydro-1H-pyrido[4,3-b]indole. L'invention a également trait à des compositions pharmaceutiques comprenant lesdits composés, ainsi qu'à des procédés d'utilisation desdits composés dans diverses applications thérapeutiques, dont le traitement d'un trouble cognitif, d'un trouble psychotique, d'un trouble médié par les neurotransmetteurs et/ou d'un trouble neuronal.
Chakravarty Sarvajit
Hung David T.
Jain Rajendra Parasmal
Protter Andrew Asher
Borden Ladner Gervais Llp
Medivation Technologies Inc.
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