New 2-azetidinone derivatives as cholesterol absorption...

C - Chemistry – Metallurgy – 07 – D

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Details

C07D 405/12 (2006.01) A61K 31/397 (2006.01) A61P 3/06 (2006.01) A61P 9/10 (2006.01) A61P 25/28 (2006.01)

Patent

CA 2609990

The invention relates to 2-azetidinone derivatives of formula (I) , including pharmaceutically acceptable salts, solvates and prodrugs thereof. The compounds inhibit cholesterol absorption and are useful in the treatment of hyperlipidaemic conditions. The invention also relates to processes for their manufacture and to pharmaceutical compositions containing them.

La présente invention concerne de nouveaux dérivés de la 2-azétidinone de formule (I) et des sels, solvates ou promédicaments pharmaceutiquement acceptables de ceux-ci. Les composés sont des inhibiteurs de l'absorption du cholestérol et sont utilisés pour le traitement de conditions d~hyperlipidémie. L'invention concerne aussi des méthodes pour leur préparation et des compositions pharmaceutiques qui les contiennent.

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