New 2-piperazinylbenzimidazole derivatives

Details New 2-piperazinylbenzimidazole derivatives New 2-piperazinylbenzimidazole derivatives

C - Chemistry, Metallurgy

07

D

C07D 403/04 (2006.01) C07D 235/30 (2006.01)

Patent

CA 2068292

ABSTRACT A PROCESS FOR PREPARING NEW 2-PIPERAZINYLBENZIMIDAZOLE DERIVATIVES A description is made of the preparation of new 2- piperazinylbenzimidazole derivatives, of general formula Image where R can be a hydrogen atom, a short chain alkyl group and a phenyl radical, substituted in position four by a halogen, and R1 can be a hydrogen atom; an alkoxycarbonyl radical, a hydroxymethyl group and a diphenylmethyl group, and their addition salts with pharmaceutically acceptable acids. These compounds are pharmacologically active as antagonists of the serotonin 5HT3 receptors.

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