New 2-substituted, 4-amino-thiazolo[4,5-d] pyrimidines,...

Details New 2-substituted, 4-amino-thiazolo[4,5-d] pyrimidines,... New 2-substituted, 4-amino-thiazolo[4,5-d] pyrimidines,...

C - Chemistry, Metallurgy

07

D

C07D 513/04 (2006.01) A61K 31/519 (2006.01) A61P 9/10 (2006.01) A61P 25/28 (2006.01) C07D 475/06 (2006.01)

Patent

CA 2541533

There are disclosed novel compounds of formula (I) wherein A, R1, R2, R3 and X are as defined in the specification, and pharmaceutically acceptable salts thereof, together with processes for their preparation, pharmaceutical compositions comprising them and their use in therapy. The compounds of formula (I) are CX3CR1 receptor antagonists and are thereby particularly useful in the treatment or prophylaxis of neurodegenerative disorders, demyelinating disease, atherosclerosis and pain.

L'invention concerne de nouveaux composés de la formule (I) où A, R?1¿, R?2¿, R?3¿ et X ont la définition donnée dans la description, et leurs sels pharmaceutiquement compatibles. L'invention concerne également leurs procédés de préparation, les compositions pharmaceutiques les contenant et leur utilisation en thérapie. Les composés de la formule (I) sont des antagonistes du récepteur CX¿3?CR1 et sont particulièrement utiles pour traitement ou prévenir les maladies neurodégénératives, la maladie de démyélinisation, l'athérosclérose et la douleur.

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