New 3,5-di-tert-butyl-4-hydroxyphenyl derivatives, processes...

C - Chemistry – Metallurgy – 07 – C

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C07C 233/00 (2006.01) A61K 31/00 (2006.01) C07C 233/19 (2006.01) C07C 233/22 (2006.01) C07C 233/73 (2006.01) C07C 233/75 (2006.01) C07C 235/20 (2006.01) C07C 235/34 (2006.01) C07C 235/78 (2006.01) C07C 237/10 (2006.01) C07C 237/20 (2006.01) C07C 255/54 (2006.01) C07C 255/57 (2006.01) C07C 275/00 (2006.01) C07C 323/41 (2006.01) C07D 207/335 (2006.01) C07D 207/337 (2006.01) C07D 209/14 (2006.01) C07D 209/18 (2006.01) C07D 209/20 (2006.01) C07D 213/02 (2006.01) C07D 213/40 (2006.01) C07D 213/56 (2006.01) C07D

Patent

CA 2115349

2115349 9304035 PCTABS00020 Described are compounds of formula (I), in which A is a valency bond or a straight or branched alkyl chain with 1 to 5 C-atoms; X is an -NR-CO (amide) or -NR-CO-NR- (urea) group in which R is a hydrogen atom or a C1-C4 alkyl group; and Y is a straight or branched, saturated or unsaturated hydrocarbon chain with 1 to 6 C-atoms (which may be substituted by an aryl, hetero-aryl, aryloxy or arylthio group), a C3-C6 cycloalkyl group or an aryl group, whereby the aryl or hetero-aryl group may be substituted in any possible positions on the ring with one to three CN, hydroxymethyl, methylenedioxy, halogen, trifluoromethyl, C1-C4 alkyl, amino, C1-C4 acylamino, di-(C1-C4)-alkylamino, hydroxy, C1-C4 alkoxy, carboxy, oxyacetic acid ethyl ester or nitro groups, with the provision that Y may only be an unsubstituted phenyl group when A is anything other than -CH2- or -CH2-CH2, as well as the pharmacologically acceptable salts of such compounds. The invention also concerns methods of preparing such compounds, and drugs containing them for the treatment of metabolic disorders.

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