New 4-substituted piperidines

Details New 4-substituted piperidines New 4-substituted piperidines

C - Chemistry, Metallurgy

07

D

C07D 211/22 (2006.01) A61K 31/4465 (2006.01) A61P 25/00 (2006.01) C07D 211/26 (2006.01) C07D 211/32 (2006.01) C07D 211/34 (2006.01)

Patent

CA 2288533

New 4-substituted piperidines New 4-substituted piperidines of general formula (I) arc described in which R1 and R2 are aryl radicals, substituted or not, which are obtained as racemic mixtures and as pure enantiomers. (SEE FORMULA I) These compounds, and their pharmaceutically acceptable salts, inhibit serotonin and/or noradrenaline reuptake, and are useful as antidepressants. Other potential therapeutic applications of these compounds are treatment of nervous bulimia, obsessive-compulsive disorders, alcohol addiction, anxiety, panic, pain, pre-menstrual syndrome and social phobia, as well as migraine prophylaxis.

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